Gain-of-Function Research: Ethical Analysis

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Gain-of-Function Research: Ethical Analysis

Gain-of-function (GOF) research involves experimentation that aims or is expected to (and/or, perhaps, actually does) increase the transmissibility and/or virulence of pathogens. Such research, when conducted by responsible scientists, usually aims to improve understanding of disease causing agents, their interaction with human hosts, and/or their potential to cause pandemics. The ultimate obje...

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When gain-of-function research is not "gain-of-function" research.

T here is ongoing discussion among the scientific and biosecurity communities over how to address concerns about “gain-of-function” (GOF) research using highly pathogenic agents [1–3]. The discussion has mainly centered on previous work by Yoshihiro Kawaoka’s group at the University of Madison-Wisconsin in the USA [4] and Ron Fouchier’s group at Rotterdam University in the Netherlands [5]. Both...

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Gain-of-function research: unproven technique.

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Ethical aspects in tissue research: thematic analysis of ethical statements to the research ethics committee

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ژورنال

عنوان ژورنال: Science and Engineering Ethics

سال: 2016

ISSN: 1353-3452,1471-5546

DOI: 10.1007/s11948-016-9810-1